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This time that friend needs to be found and in the process Finding Dory opens to the tune of $136 million, the highest ever for an animated film.
It also managed the highest ever single day openeing with nearly $55 million and you have one hell of a hit film on your hands.
Critics have been favourable although the general thought is the film is not as good as its predecessor Finding Nemo.
Last weeks top film The Conjuring 2 falls quite hard this week to number 3 with a weekend take of $15.5 million and a total gross of $71 million.
Highest total grossing movie on the US box office is Captain America: Civil War with $401 million, and it is also the longest running movie with 7 weeks on the top 10.