| pos. | Title | Gross | |
|---|---|---|---|
| 1 |  | Top Gun: Maverick (2022) | $717,041,054 |
| 2 |  | Black Panther: Wakanda Forever (2022) | $438,291,367 |
| 3 |  | Avatar: The Way of Water (2022) | $425,527,069 |
| 4 |  | Doctor Strange In the Multiverse of Madness (2022) | $411,327,261 |
| 5 |  | Jurassic World: Dominion (2022) | $375,989,145 |
| 6 |  | Minions: The Rise of Gru (2022) | $369,461,180 |
| 7 |  | The Batman (2022) | $369,342,756 |
| 8 |  | Thor: Love and Thunder (2022) | $343,249,558 |
| 9 |  | Sonic the Hedgehog 2 (2022) | $190,843,518 |
| 10 |  | Black Adam (2022) | $168,076,272 |
| 11 |  | Elvis (2022) | $151,032,908 |
| 12 |  | Uncharted (2022) | $148,195,223 |
| 13 |  | Nope (2022) | $123,248,570 |
| 14 |  | Lightyear (2022) | $118,304,889 |
| 15 |  | Smile (2022) | $105,897,742 |
| 16 |  | The Lost City (2022) | $105,276,064 |
| 17 |  | Bullet Train (2022) | $103,360,044 |
| 18 |  | The Bad Guys (2022) | $97,210,660 |
| 19 |  | Fantastic Beasts: The Secrets of Dumbledore (2022) | $95,554,501 |
| 20 |  | DC League of Super-Pets (2022) | $93,656,188 |