| pos. | Title | Gross | |
|---|---|---|---|
| 1 |  | How the Grinch Stole Christmas (2000) | $211,725,050 |
| 2 |  | The Perfect Storm (2000) | $182,544,920 |
| 3 |  | X-Men (2000) | $157,299,718 |
| 4 |  | Scary Movie (2000) | $156,051,457 |
| 5 |  | Meet the Parents (2000) | $155,415,770 |
| 6 |  | What Lies Beneath (2000) | $155,100,464 |
| 7 |  | Nutty Professor II: The Klumps (2000) | $123,218,360 |
| 8 |  | Charlie's Angels (2000) | $114,725,901 |
| 9 |  | The Patriot (2000) | $112,408,069 |
| 10 |  | Remember the Titans (2001) | $111,017,768 |
| 11 |  | What Women Want (2001) | $110,187,561 |
| 12 |  | Chicken Run (2000) | $105,345,802 |
| 13 |  | Cast Away (2000) | $100,628,594 |
| 14 |  | Me, Myself & Irene (2000) | $89,979,930 |
| 15 |  | Space Cowboys (2000) | $89,699,441 |
| 16 |  | Hollow Man (2000) | $73,161,416 |
| 17 |  | The Kid (2000) | $68,320,201 |
| 18 |  | Bring It On (2000) | $68,117,960 |
| 19 |  | Gone In 60 Seconds (2000) | $67,572,615 |
| 20 |  | Big Mommas House (2000) | $58,068,132 |