| pos. | Title | Gross | |
|---|---|---|---|
| 1 |  | Pirates of the Caribbean: Dead Man's Chest (2006) | $423,271,331 |
| 2 |  | Cars (2006) | $244,052,771 |
| 3 |  | X-Men: The Last Stand (2006) | $234,360,014 |
| 4 |  | The Da Vinci Code (2006) | $217,536,138 |
| 5 |  | Superman Returns (2006) | $200,069,408 |
| 6 |  | Ice Age: The Meltdown (2006) | $195,327,048 |
| 7 |  | Happy Feet (2006) | $175,967,627 |
| 8 |  | Over the Hedge (2006) | $154,966,834 |
| 9 |  | Casino Royale (2006) | $153,531,944 |
| 10 |  | Talladega Nights: The Ballad of Ricky Bobby (2006) | $148,213,377 |
| 11 |  | Click (2006) | $137,340,146 |
| 12 |  | Mission:Impossible III (2006) | $133,382,309 |
| 13 |  | Borat: Cultural Learnings of America For Make Benefit Glorious Nation of Kazakhstan (2006) | $125,601,414 |
| 14 |  | The Devil Wears Prada (2006) | $124,739,606 |
| 15 |  | The Departed (2006) | $120,359,613 |
| 16 |  | The Break Up (2006) | $118,668,645 |
| 17 |  | Night At the Museum (2006) | $115,822,154 |
| 18 |  | The Pursuit of Happyness (2007) | $98,411,670 |
| 19 |  | Scary Movie 4 (2006) | $90,703,745 |
| 20 |  | Failure to Launch (2006) | $88,658,172 |