| pos. | Title | Gross | |
|---|---|---|---|
| 1 |  | The Dark Knight (2008) | $530,544,468 |
| 2 |  | Indiana Jones and the Kingdom of the Crystal Skull (2008) | $305,318,444 |
| 3 |  | Iron Man (2008) | $258,523,409 |
| 4 |  | Hancock (2008) | $186,672,707 |
| 5 |  | Kung-Fu Panda (2008) | $185,322,664 |
| 6 |  | Madagascar Escape 2 Africa (2008) | $167,172,587 |
| 7 |  | Quantum of Solace (2008) | $151,853,483 |
| 8 |  | Twilight (2008) | $144,937,012 |
| 9 |  | Mamma Mia! (2008) | $143,704,210 |
| 10 |  | Sex and the City (2008) | $142,581,151 |
| 11 |  | WALL•E (2008) | $129,025,476 |
| 12 |  | The Incredible Hulk (2008) | $111,613,740 |
| 13 |  | Tropic Thunder (2008) | $110,515,313 |
| 14 |  | Juno (2008) | $109,212,489 |
| 15 |  | The Mummy: Tomb of the Dragon Emperor (2008) | $102,176,165 |
| 16 |  | Journey to the Center of the Earth (2008) | $101,689,940 |
| 17 |  | Eagle Eye (2008) | $100,903,133 |
| 18 |  | Step Brother's (2008) | $100,468,793 |
| 19 |  | National Treasure: Book of Secrets (2008) | $93,028,293 |
| 20 |  | Beverly Hills Chihuahua (2008) | $92,923,293 |