| pos. | Title | Gross | |
|---|---|---|---|
| 1 |  | Spider-Man: No Way Home (2021) | $613,600,664 |
| 2 |  | Shang-Chi and the Legend of the Ten Rings (2021) | $224,537,817 |
| 3 |  | Venom: Let There Be Carnage (2021) | $212,638,437 |
| 4 |  | Black Widow (2021) | $183,647,307 |
| 5 |  | Fast and Furious 9 (2021) | $173,003,090 |
| 6 |  | Eternals (2021) | $164,694,402 |
| 7 |  | No Time To Die (2021) | $160,538,078 |
| 8 |  | A Quiet Place: Part II (2021) | $160,039,291 |
| 9 |  | Ghostbusters: Afterlife (2021) | $123,420,032 |
| 10 |  | Free Guy (2021) | $121,623,717 |
| 11 |  | Jungle Cruise (2021) | $116,987,516 |
| 12 |  | Dune (2021) | $107,215,864 |
| 13 |  | Godzilla Vs. Kong (2021) | $99,706,155 |
| 14 |  | Halloween Kills (2021) | $91,998,225 |
| 15 |  | Encanto (2021) | $91,386,126 |
| 16 |  | Sing 2 (2021) | $90,247,305 |
| 17 |  | The Emperors New Groove (2001) | $89,636,687 |
| 18 |  | Cruella (2021) | $86,110,061 |
| 19 |  | Space Jam: A New Legacy (2021) | $69,480,599 |
| 20 |  | The Conjuring: The Devil Made Me Do It (2021) | $64,609,158 |