The big green ogre once again out grosses the rest of the box office, although with a really low gross over the weekend, all it took was $25.3 Million to manage stay on top.
Shrek number four has now taken just over $183 million in total grosses in the US.
The UK's very own Russell Brand returns as the arrogant pop singer Aldous Snow in Get Him to the Greek, but it only takes $17,422,620 in a very poor debut weekend.
Rounding out the top 3 in Ashton Kutcher and Katherine Heigl in Killers taking just over $16 million.