FOR 22 YEARS
| pos. | Title | Gross | |
|---|---|---|---|
| 1 |  | Avatar (2009) | $2,115,820,720 |
| 2 |  | Despicable Me (2010) | $540,517,025 |
| 3 |  | Harry Potter and the Deathly Hallows Part 1 (2010) | $330,017,372 |
| 4 |  | Resident Evil: Afterlife (2010) | $286,652,810 |
| 5 |  | Megamind (2010) | $285,484,566 |
| 6 |  | The Expendables (2010) | $262,566,420 |
| 7 |  | TRON Legacy (2010) | $229,902,433 |
| 8 |  | Eat Pray Love (2010) | $184,685,119 |
| 9 |  | Due Date (2010) | $183,290,557 |
| 10 |  | Knight and Day (2010) | $182,449,299 |
| 11 |  | Red (2010) | $169,110,768 |
| 12 |  | Legend of the Guardians: The Owls of Ga'hoole (2010) | $167,086,600 |
| 13 |  | The Other Guys (2010) | $166,962,566 |
| 14 |  | The Social Network (2010) | $165,675,719 |
| 15 |  | Jackass 3D (2010) | $164,095,498 |
| 16 |  | Paranormal Activity 2 (2010) | $162,827,618 |
| 17 |  | The Princess and the Frog (2010) | $143,948,516 |
| 18 |  | Unstoppable (2010) | $129,017,794 |
| 19 |  | Wall Street: Money Never Sleeps (2010) | $120,259,356 |
| 20 |  | A Nightmare On Elm Street (2010) | $102,288,269 |