| pos. | Title | Gross | |
|---|---|---|---|
| 1 |  | Avatar (2009) | $467,963,247 |
| 2 |  | Toy Story 3 (2010) | $414,984,497 |
| 3 |  | The Twilight Saga: Eclipse (2010) | $300,523,113 |
| 4 |  | Harry Potter and the Deathly Hallows Part 1 (2010) | $253,400,939 |
| 5 |  | Despicable Me (2010) | $250,866,910 |
| 6 |  | Shrek Forever After (2010) | $238,319,043 |
| 7 |  | Inception (2010) | $226,185,694 |
| 8 |  | Iron Man 2 (2010) | $215,515,110 |
| 9 |  | The Karate Kid (2010) | $176,333,984 |
| 10 |  | Grown Ups (2010) | $162,001,186 |
| 11 |  | Sherlock Holmes (2009) | $139,686,012 |
| 12 |  | Alvin and the Chipmunks: The Squeakquel (2009) | $138,027,113 |
| 13 |  | Megamind (2010) | $136,718,814 |
| 14 |  | Tangled (2010) | $135,464,411 |
| 15 |  | Clash of the Titans (2010) | $135,040,998 |
| 16 |  | The Last Airbender (2010) | $131,564,731 |
| 17 |  | TRON Legacy (2010) | $131,304,844 |
| 18 |  | The Other Guys (2010) | $119,219,978 |
| 19 |  | Salt (2010) | $118,311,368 |
| 20 |  | Jackass 3D (2010) | $116,886,069 |